Goals MNIMBS Set For Itself At Its Beginning
Results of the Application of Nanotechnology
- Multifunctional "Smart" Therapeutics
- Drug/gene delivery with targeting and regulation
- Imaging/Sensing/Response
- Controlled Release Analgesics
- Molecular Surgery
- New Sensor Systems
- Remote, real-time medical monitoring
- Smart environmental monitors
- Functional Augmentation: Improved Strength, Memory, etc.
- Synthetic Replacement Materials
- New Bio-inspired Materials
- A Nanobiology certificate program that harnesses nanomedicine applications
Examples of Federal Contracts and Proposals that have been submitted from the Institute
A few examples of teams of interdisciplinary nanobiology scientists the Institute might be expected to support. All are strongly interdisciplinary and involve multiple colleges.
- A Center for Excellence in Cancer Nanotechnology; we applied in 2005 and 2010
- A Nanomedicine Center
- A EFRI on bio–inspired nanomaterials
- Training grant for biological nanotechnology at Michigan
- Center for Optics at the Nanoscale in the Life Sciences
We continue to work on becoming the home to one or more externally funded centers. We have already had a number of collaborative grants and contracts awarded in the areas where Nanoscience intersects with the Biological and Medical Sciences. We list some examples of multidisciplinary funded projects here.
Sponsor: NIH-NCI
Dates: 9/30/2005-8/31/2008
Title: Photonic Crystal Fiber Probe Fluorescence Biosensing
PI & Collaborators: James R. Baker, Jr. (PI), Thommey Thomas, Ted Norris, Jingyong Ye, Xiangyang Shi, Jolanta Kukowska-Latallo
Total Direct Costs: $768,435
Sponsor: NIH
Dates: 9/21/2005-7/31/2009
Title: Photonic Crystal Technology for Biomolecular Assay
PI & Collaborators: Ted Norris (PI), Jingyong Ye, James R. Baker, Jr., Thommey Thomas, Andrzej Myc
Total Direct Costs: $ $364,487
Sponsor: NIH
Dates: 9/29/2005-8/31/2010
Title: DNA-Linked Dendrimer Nanoparticle Systems for
Cancer Diagnosis and Treatment
PI & Collaborators: James R. Baker, Jr. (PI),Jolanta Kukowska-Latallo, Istvan Majoros, Mark Banaszak Holl, Theodore B. Norris, Brad Orr, Andrzej Myc, Seok Ki Choi, Baohua Huang, Thommey P. Thomas
Total Costs: $2,491,723
Sponsor: DARPA
Dates: 7/01/2008-3/31/2012
Title: Battlefield Analgesics with Physiological Feedback
Control, Phase II
PI & Collaborators: James R. Baker, Jr. (PI), Baohua Huang, Thommey Thomas, Brent Ward, Abraham VanDerSpek, Yuehua Zhang, Seok-Ki Choi, Mark Banaszak Holl, Brad Orr
Total Direct Costs: $3,671,656
Sponsor: DOD
Dates: 10/15/2010-11/14/2013
Title: Nanoemulsion-Based Anti-Microbials for Protection
Against Burn and Wound Infections
PI & Collaborators: James R. Baker, Jr. (PI), Douglas M. Smith, Andrzej Myc, Paul Makidon, Mark R. Hemmila, John LiPuma
Total Costs: $1,476,040
Sponsor: NIH
Dates: 12/01/2007–11/30/2012
(Subcontract: U. of Wisconsin, Madison)
Title: Neuraminidase-Deficient Influenza Vaccines
with Nanoemulsions as Adjuvants
PI & Collaborators: Y. Kawaoka (PI), James R. Baker, Jr., Andrzej Myc
Total Direct Costs: $1,245,911
Sponsor: NIH
Dates: 8/15/2010-5/31/2014
Title: The Role of Cell Membrane Disruption in Non-Viral
Vector Oligonucleotide Delivery
PI & Collaborators: Mark M. Banaszak Holl (PI), James R. Baker, Jr., Jolanta Kukowska-Latallo, Bradford G. Orr
Total Costs: $1,732,044
Sponsor: NSF Dates: 9/1/2009-8/31/2012
Title: MRI: Acquisition of an Ultrahigh Resolution Electron-Beam
Lithography System for the University of Michigan
Lurie Nanofabrication Facility
PI & Collaborators: Stella W. Pang, (PI), James R. Baker, Kensall D. Wise, Pallab K., Bhattacharya, Stephen R. Forrest
Total Direct Costs: $1,700,000
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