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Anna Mapp, PhD

Professor of Chemistry, College of Literature, Science, and the Arts and Director, Interdisciplinary Programs, Rackham Graduate School

Chemistry
930 N Univ
SPG 1055

734/763-6148

amapp@umich.edu

Dr. Mapp works on developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. Regulated gene expression is critical for cellular existence, and a number of human diseases such as cancer and diabetes have been linked to aberrant patterns of gene expression. She works on the discovery of transcription-based therapeutics capable of reprogramming gene expression in diseased cells while leaving normal cells unaffected. While a general sequence of events that leads to gene up-regulation is agreed upon, the molecular-level interactions that regulate the levels and time course of transcriptional activation remain unknown. A more detailed picture of gene regulation is a prerequisite for the eventual development of transcription-based therapeutics.

 

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