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Two Photon Fluorescence Spectroscopy

In vivo Cytometry

Figure 1: In vivo Cytometry
A Next Generation Diagnostic Tool

 

Flow Cytometry's in vivo potential:

  • Diagnosis of infectious diseases, such as AIDS, SARS
  • Identification of epidemics or bioterrorism events
  • Real-time health monitoring
  • Cancer research, such as metastasis studies
  • Pharmaceutical research, such as drug delivery studies

Further information on this technology will be posted soon.
Ye JY, Myaing MT, Norris TB, Thomas TP, Baker JR, Jr.: Biosensing based on two–photon fluorescence measurements through optical fibers. Optic Letters, 2002:27(16), 1412–1414.

Eric R. Tkaczyk, Cheng Frank Zhong, Jing Yong Ye, Steve Katnik, Andrzej  Myc, Kathryn E. Luker, Gary D. Luker, James R. Baker, Jr., and Theodore B. Norris, "Two-photon, Two-color in Vivo Flow Cytometry to Noninvasively Monitor Multiple Circulating Cell Lines," Multiphoton Microscopy in the Biomedical Sciences VI, Proceedings of SPIE 6631, 2007.

Myaing MT, Ye JY, Norris TB, Thomas T, Baker JR Jr., Wadsworth WJ, Bouwmans G, Knight JC, and Russell PS: Enhanced two–photon biosensing with double–clad photonic crystal fibers. Optics Letters, 2003:28(14), 1224–1226.

Eric R. Tkaczyk, Cheng Frank Zhong, Jing Yong Ye, Andrzej Myc, Thommey Thomas, Zhengyi Cao, Raimon Duran-Struuck, Kathryn E. Luker, Gary D. Luker, Theodore B. Norris and James R. Baker, Jr.  In Vivo Monitoring of Multiple Circulating Cell Populations Using Two-photon Flow Cytometry. Optics Communication, 2008, In press.

 

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