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2013 Publications


Ward BB, Huang B, Desai A, Cheng XM, Vartanian M, Zong H, Shi X, Thomas TP, Kotlyar AE, Van Der Spek A, Leroueil PR, Baker JR Jr. Sustained analgesia achieved through esterase-activated morphine prodrugs complexed with PAMAM dendrimer. Pharm Res. 2013 Jan;30(1):247-56.


Myc A, Kukowska-Latallo JF, Smith DM, Passmore C, Pham T, Wong PT, Bielinska AU, Baker JR Jr. Nanoemulsion nasal adjuvant W805EC induces dendritic cell engulfment of antigen-primed epithelial cells. Vaccine. 2013 Feb 4;31(7):1072-9. PMCID: PMC3556236


Choi SK, Myc A, Silpe JE, Sumit M, Wong PT, McCarthy K, Desai AM, Thomas TP, Kotlyar A, Holl MM, Orr BG, Baker JR Jr. Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface. ACS Nano. 2013 Jan 22;7(1):214-28. PMID: 232596666


Leung S, Smith D, Myc A, Morry J, Baker JR Jr. OT-II TCR transgenic mice fail to produce anti-ovalbumin antibodies upon vaccination. Cell Immunol. 2013 Apr;282(2):79-84. PMID: 23770715


Cline EN, Li MH, Choi SK, Herbstman JF, Kaul N, Meyhöfer E, Skiniotis G, Baker JR, Larson RG, Walter NG. Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action. Biomacromolecules. 2013 Mar 11;14(3):654-64. PMCID: PMC3603340


Matz RL, Erickson B, Vaidyanathan S, Kukowska-Latallo JF, Baker JR Jr, Orr BG, Banaszak Holl MM. Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division. Mol Pharm. 2013 Apr 1;10(4):1306-17. PMCID: PMC3637663


Goonewardena SN, Kratz JD, Zong H, Desai AM, Tang S, Emery S, Baker JR Jr, Huang B. Design considerations for PAMAM dendrimer therapeutics. Bioorg Med Chem Lett. 2013 May 15;23(10):2872-5. PMID:23583511


Thomas TP, Joice M, Sumit M, Silpe JE, Kotlyar A, Bharathi S, Kukowska-Latallo J, Baker JR, Choi SK. Design and In Vitro Validation of Multivalent Dendrimer Methotrexates as a Folate-targeting Anticancer Therapeutic. Curr Pharm Des. 2013;19(37):6594-605. PMCID: PMC3859140


Baker JR Jr. Why I believe nanoparticles are crucial as a carrier for targeted drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Sep-Oct;5(5):423-9. PMID: 23633301


Inlay MA, Choe V, Bharathi S, Fernhoff NB, Baker JR Jr, Weissman IL, Choi SK. Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification. Chem Commun (Camb). 2013 May 28;49(43):4971-3. PMCID: PMC3926663


Smith DM, Simon JK, Baker JR Jr. Applications of nanotechnology for immunology. Nat Rev Immunol. 2013 Aug;13(8):592-605.  PMID: 23883969


van Dongen MA, Desai A, Orr BG, Baker JR Jr, Holl MM. Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer. Polymer (Guildf). 2013 Jul 19;54(16):4126-4133. PMCID: PMC3775363


Yu S, Li MH, Choi SK, Baker JR, Larson RG. DNA condensation by partially acetylated poly(amido amine) dendrimers: effects of dendrimer charge density on complex formation. Molecules. 2013 Sep 3;18(9):10707-20.  


Chang HN, Leroueil PR, Selwa K, Gasper CJ, Tsuchida RE, Wang JJ, McHugh WM, Cornell TT, Baker JR Jr, Goonewardena SN. Profiling inflammatory responses with microfluidic immunoblotting. PLoS One. 2013 Nov 27;8(11) PMCID: PMC3842271


Goonewardena SN, Leroueil PR, Gemborys C, Tahiliani P, Emery S, Baker JR, Zong H. Fluorogenic 'click-on' dendrimer reporter for rapid profiling of cell proliferation. Bioorg. Med. Chem. Lett. 2013;23(7):2230-2233 PMID:23434421


Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, Chang AE, Xia JC, Baker JR Jr, Li Q. Characterization of a Novel Transgenic Mouse Tumor Model for Targeting HER2+ Cancer Stem Cells. Int J Biol Sci. 2013 Dec 6;10(1):25-32. PMCID: PMC3879588


Silpe JE, Sumit M, Thomas TP, Huang B, Kotlyar A, van Dongen MA, Banaszak Holl MM, Orr BG, Choi SK. Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles.  ACS Chem Biol 2013 Sept 20; 8(9):2063-71. PMCID: PMC3783574


Rattan R, Vaidyanathan S, Wu GS, Shakya A, Orr BG, Banaszak Holl MM. Polyplex-induced cytosolic nuclease activation leads to differential transgene expression. Mol Pharm 2013 Aug 5; 10(8):3013-22. PMCID: PMC3776314


Goonewarden SN, Zong H, Leroueil PR, Baker JR Jr. Bioorthogonal chemical handle for tracking multifunctional nanoparticles. ChemPlusChem 2013, 78(5):430-437.


Izhak L, Ambrosino E, kato S, Parish ST, O'Konek JJ, Weber H, Xia Z, Venson D, Berzofsky JA, Terabe M. Delicate balance among three types of T cells in concurrent regulation of tumor immunity.  Cancer Res 2013 Mar 1; 73(5):1514-23. PMCID: PMC3622595


O'Konek JJ, Kato S, Takao S, izhak L, Xia Z, Illarionov P, Besra GS, Terabe M, Berzofsky JA. β-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy. Clin Cancer Res 2013 Aug 15; 19(16):4404-11. PMCID: PMC3819527


Zheng L, Zhu J, Shen M, Chen X, Baker JR Jr., Wang SH, Zhang G, Shi X. Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles. Med Chem Comm 2013; 4:1001-1005.



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