MNIMBS
Graduate Students
 

Daniel McNerny 
B.S. Chemical Engineering, Biomedical Engineering
Carnegie Mellon University
M.S. Chemical Engineering
University of Michigan
Ph.D. candidate
Department of Chemical Engineering (2005-present)

Project: Design of Poly(amidoamine) Dendron Synthetic Avidity Agents Utilizing Initiation Site Coupling
Advisor: James R. Baker Jr., MD

About Dan: Dan graduated from Carnegie Mellon in 2005 and joined MNIMBS upon his arrival in Michigan that fall.  His thesis project involves designing a dendron targeted delivery platform that reduces the product heterogenity found in traditional dendritic platforms.

Dan serves as the GSI for the NanoBiology Certificate Program Seminar: Winter 2009, Fall 2009, Winter 2010. General information on the Certificate Program.

Publications

McNerny, Daniel Q.; Mullen, D. G.; Majoros, I. J.; Banaszak Holl, M. M.; Baker, J. R. Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications. In Click Chemistry for Biotechnology and Material Science (ed. Joerg Lahann), Wiley, 2009.

McNerny, Daniel Q.; Leroueil, P. R.; Baker, J. R. Understanding specific and non-specific toxicities; A requirement for the development of dendrimer-based pharmaceuticals. Nanomedicine and Nanobiotechnology (2009), accepted.

McNerny, Daniel Q.; Kukowska-Latallo, J. F; Mullen, D. G.; Wallace, J. M.; Desai, A. M.; Shukla, R.; Huang, B.; Banaszak Holl, M. M.; Baker, J. R. RGD Dendron Bodies; Synthetic Avidity Agents with Defined and Potentially Interchangeable Effector Sites That Can Substitute for Antibodies. Bioconjugate Chemistry (2009), ASAP.

Mullen, D. G.; Desai, A. M.; Waddell, J. N.; Cheng, X.; Kelly, C. V.; McNerny, Daniel Q.; Majoros, I. J.; Baker, J. R.; Sander, L. M.; Orr, B. G.; Banaszak Holl, M. M. The Implications of Stochastic Synthesis for the Conjugation of Functional Groups to Nanoparticles. Bioconjugate Chemistry (2008), 19(9), 1748-1752.

Leroueil, P. R.; Berry, S. A.; Duthie, K.; Han, G.; Rotello, V. M.; McNerny, Daniel Q.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Letters (2008), 8(2), 420-424.

Douglas Mullen, BSE

B.S.E. Mechanical Engineering
Duke University
M.S.E. Macromolecular Science and Engineering
University of Michigan

Ph.D. candidate
Macromolecular Science and Engineering (2005-present)

Project: Design of Multi-Functional Drug Delivery Platforms
Advisor: Mark Banaszak Holl, PhD

About Doug: Doug received a Bachelor's of Science in Engineering from Duke University in 2005. In 2007 Doug received a Master's of Science in Engineering from the University of Michigan's Program in Macromolecular Science and Engineering and in 2009 he completed the MBA Essentials and Entrepreneurship Program at Michigan's Ross School of Business. He is presently a Doctoral Candidate in the Macromolecular Science and Engineering Program and his thesis work involves the development of targeted chemotherapeutic agents. He has received several awards including the Raymond C. Gaugler Award in Materials Science and Engineering at Duke, the Rackham Regents Fellowship at the University of Michigan, an award for Excellence in Graduate Polymer Research from the American Chemical Society, and the National Starch and Chemical Award from the Macromolecular Science and Engineering Program at the University of Michigan.

Doug is a former member of the Duke Sailing Team and currently sings with the U of M Law School's a cappella group, the Headnotes.


Publications

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

J. Chen, J. A. Hessler, K. Putchakayala, B. K. Panama, D. P. Khan, S. Hong, D. G. Mullen, S. C. DiMaggio, A. Som, G. N. Tew, A. N. Lopatin, J. R. Baker, M. M. Banaszak Holl, B. G. Orr Journal of Physical Chemistry B 2009, 113, 11179-11185.

The Role of Ganglioside GM1 in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers S. Hong, R. Rattan, I. Majoros, D. G. Mullen, J. L. Peters, X. Shi, A. U. Bielinska, L. Blanco, B. G. Orr. J. R. Baker, M. M. Banaszak Holl Bioconjugate Chemistry 2009, 20, 1503-1513.

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes

C. V. Kelly, M. G. Liroff, L. D. Triplett, P. R. Leroueil, D. G. Mullen, J. M. Wallace, S. Meschinchi, J. R. Baker, B. G. Orr, M. M. Banaszak Holl ACS Nano 2009 3, 1886-1896.

Mullen, D. G.; Desai, A. M.; Waddell, J. N.; Cheng, X-M.; Kelly, C. V.; McNerny, D. Q.; Majoros, I. J.; Baker, J. R.; Sander, L. M.; Orr, B. G.; Banaszak Holl, M. M. The Implications of Stochastic Synthesis for the Conjugation of Functional Groups to Nanoparticles. Bioconjugate Chemistry 2008, 19 (9), 1748-1752
(link)
.

Interaction of Poly(amidoamine) Dendrimers with Survanta Lung Surfactant:  The Importance of Lipid Domains B. Erickson, S. DiMaggio, D. G. Mullen, C. V. Kelly, P. R. Leroueil, S. A. Berry, J. R. Baker, Jr., B. G. Orr, M. M. Banaszak Holl Langmuir 2008 24 11003-11008.


Meredith Brenner
B.S. Physics
University of Maryland at College Park
Ph.D. pre-candidate
Applied Physics (2007-present)

Project: Pulse-shaping Multi-photon FRET Microscopy
Advisor: Jennifer Ogilvie, PhD

About Meredith:  Meredith graduated cum laude from the University of Maryland at College Park in 2007, where she

earned a B.S. with honors in physics, completed a second major in psychology, and was elected to Phi Beta Kappa.  Meredith is currently working towards her Ph. D. in Applied Physics, researching the application of laser pulse shaping techniques to nonlinear microscopy. She is a recipient of the NIH Molecular Biophysics Training Grant, the Rackham Merit Fellowship, and the University Regents’ Fellowship. Outside of the lab, Meredith is a member of the University of Michigan Women’s Glee Club 

Presentations

“Pulse Shaping Multiphoton FRET Microscopy” Poster presentation at the 2009 Herbert D. Doan Nanotechnology Symposium, University of Michigan MNIMBS

“Flow Visualization of Heated CO2 Gas Using Thermal Imaging” Presented at the SPIE Thermosense XXVIII Conference, April 2006.

Conference proceedings

H. Yoon, M. Brenner, J.P. Rice, N. R. Briggs, and G. Gillen, in the Proceedings of SPIE Vol. 6205, Thermosense XXVIII. Edited by Jonathan J. Miles, G. Raymond Peacock, and Kathryn M. Knettel, April 2006.

 

Ming (Flora) Fang 
B.S. Chemistry
University of Science and Technology of China

Ph.D. pre-candidate
Department of Chemistry (2008-present)

Project: Collagen fibril morphology in healthy and estrogen depleted ovine bone
Advisor: Mark Banaszak Holl
, PhD

About Flora: Flora received a B.S. in chemistry from University of Science and Technology of China in 2008. At USTC, she did research using state of the art Guassian 3 to study quantitative structure-property relationship of tetrathiafulvalene analogs. Here at Michigan, Flora is a materials chemistry graduate student advised by professor Mark Banaszak Holl. Her research is aimed at understanding bone collagen changes occurring in sheep and humans with osteoporosis disease.

Yunbo Guo
B.S. Mechanical Engineering
Tsinghua Universiyty
M.S. Optical Engineering
Tsinghua University
Ph.D. candidate
Department of Electrical Engineering and Computer Science (2005-present)

Project: Development and biomedical application of a novel label-free photonic crystal sensor
Advisor: Theodore Norris, PhD

About Yunbo: Yunbo got his B.S. in Mechanical Engineering (2002) and M.S. in Optical Engineering (2005) both from Tsinghua University. His M.S. research was focused on optimization of holographic data storage and correlation recognition system, and he was honored as "Scientific and Technological Achievement Completer" by China Ministry of Education in 2004.

Currently he is developing a novel optical biosensors for biomolecular binding analysis, which has achieved significantly higher sensitivity than the state-of-the-art surface plasmon resonance based instrument, and will allow people to perform binding studies that are currently out of reach of those systems already on the market. His work was turned into a patent and is being commercialized.

Awards

2009 First prize winner of poster competition in Optics at Engineering Graduate Symposium
2009 First prize winner of poster competition at Herbert D. Doan Nanotechnology Symposium
2008, 2009 Rackham conference travel grant, the University of Michigan
2008 First prize winner of poster competition in Biomedical Imaging at Engineering Graduate Symposium
2007-2008 Riethmiller fellowship, the University of Michigan
2005-2006 EECS department fellowship, the University of Michigan
2004 Scientific and technological achievement completer, China Ministry of Education
2004 Excellent research award, Tsinghua University
2001 Excellent academic award, Tsinghua University
1999 Outstanding student award, Tsinghua University
1998 Outstanding freshman award, Tsinghua University

Publications
Y. Guo, C. Divin, A. Myc, F. L. Terry, Jr., J. R. Baker, Jr., T. B. Norris, and J. Y. Ye, "Sensitive bioassay using a photonic crystal structure in total internal reflection," Opt. Express 16, 11741 -11749 (2008).


Y. Guo, Y. Liao, L. Cao, G. Liu, Q. He and G. Jin, "Improvement of photorefractive properties and holographic applications of lithium niobate crystal," Opt. Express 12, 5556-5561 (2004).


Y. Liao, Y. Guo, L. Cao, X. Ma, Q. He, G. Jin, "Experiment on parallel correlated recognition of 2030 human faces based on speckle modulation," Opt. Express 12, 4047-4052 (2004).

Conference Publications
Y. Guo, J. Y. Ye, B. Huang, D. McNerny, T. P. Thomas, J. R. Baker, Jr. and T. B. Norris, "Real-time small molecule binding detection using a label-free optical biosensor," SPIE proceedings 2010 , accepted

Y. Guo, T. P. Thomas, J. Y. Ye, A. Myc, J. R. Baker, Jr. and T. B. Norris, "Real-time, label-free protein binding detection with a one dimensional photonic crystal sensor," paper CTuCC6, CLEO (2009).


Y. Guo, J. Y. Ye, C. Divin, T. P. Thomas, A. Myc, T. Begey, J. Baker and T. B. Norris, "Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry," Proc. of SPIE 7188, 71880B (2009).

Y. Guo, J. Y. Ye, C. Divin, A. Myc, J. R. Baker, Jr. and T. B. Norris, "Optical biosensor based on one-dimensional photonic crystal in a total-internal-reflection geometry," paper CThZ3, CLEO (2008).


G. Liu, J. Wang, Y. Guo and S. Wang, "The influence of photovoltaic Dc field on holographic correlation recognition," Proc. of SPIE 6027, 60272J (2006).


Q. He, Y. Guo, Y. Liao, L. Cao, G. Liu and G. Jin, "Holographic properties of doubly doped lithium niobate crystals with Indium," Proc. of SPIE 5636, 312-320 (2005).

Q. He, Y. Liao, Y. Guo, L. Cao, X. Ma and G. Jin, "Improvement to large capacity pattern recognition using speckle modulation and suitable time schedule," Proc. of SPIE 5636, 321-328 (2005).


Y. Guo, J. Wang, Q. He, M. Wu and G. Jin, "Study of the holographic storage properties of In: Fe: LiNbO3 crystal in electrolytic solution," General Congress of Chinese Optical Society, NO.6, 110-114 (2004).

Alexander Hrin
B.S. Engineering Physics
Colorado School of Mines
M.S. Applied Physics
Colorado School of Mines
Ph.D. pre-candidate
Biophysics (2008-present)

Project: Detection of DNA through the Asynchronous Rotation Tecnique
Advisor: Raoul Kopelman, PhD

About Alex: Alex graduated from Colorado School of Mines in 2007 with a B.S. in Engineering Physics and in 2008 with a M.S. in Applied Physics.  He entered the University of Michigan Biophysics Graduate Program in 2008.  His thesis project involves detection of DNA through the use of rotating magnetic particles.

Publications

Adams DE, Planchon TA, Hrin A, Squier JA, Durfee CG. Characterization of coupled nonlinear spatiospectral phase following an ultrafast self-focusing interaction. Optics Letters, 2009.

Paivo Kinnunen

B.S. Physics
Minors in Mathematics and Computer Science
University of Turku, Finland

Ph.D. candidate
Applied Physics (2007-present)

Project:  Emerging Microbiological Sensor - Asynchronous Rotation of Magnetic Beads 
Advisor: Raoul Kopelman, PhD

About Paivo: Paivo received his BS from the University of Turku after completing a year long exchange program at the University of Michigan in 2007. He started Applied Physics program at the UofM the same year, joining Professor Kopelman's research group in 2008 where he currently is a doctoral candidate. 

Recent Publication:

McNaughton, B. H, P. Kinnunen, R. G Smith, S. N Pei, R. Torres-Isea, R. Kopelman, and R. Clarke. “Compact sensor for measuring nonlinear rotational dynamics of driven magnetic microspheres with biomedical applications.” Journal of Magnetism and Magnetic Materials (2009).

Paivo's work highlighted on Mlive.com

 

Shelly Lueng
B.S. Biochemistry
University of Michigan
Ph.D. pre-candidate
Graduate Program in Immunology (2008-present)

Project: Elucidating the role of immunogolic memory in the anti-tumor response upon vaccination with nanoemulsion adjuvant
Advisor: James R. Baker Jr., MD

About Shelly: Shelly graduated from the University of Michigan in 2008 with a degree in Biochemistry. She did her undergraduate research in the field of Systems and Synthetic

Biology, focusing on building and characterizing genetic bistable switches to generate memory in E. coli. Her current research interests have shifted towards a more translational focus in the field of Immunology.


Publications

Chang DE, Leung S, Reifler AN, Atkinson MR, Forger DB, Ninfa AJ. 2009. Building biological memory by linking positive feedback loops. Proc Natl Acad Sci USA. (Revisions in progress)

Christopher Sarra
B.S. Materials Science and Engineering
Cornell University
Ph.D. pre-candidate
Macromolecular Science and Engineering (2009-present)

Advisor: Mark Banaszak Holl, PhD


About Chris: Chris graduated from Cornell University in May 2009 with a B.S. in Materials Science and Engineering. As an undergraduate, he worked on a co-advised research project in both the Wiesner and Estroff Research Groups. At the University of Michigan, Chris is working toward a PhD in Macromolecular Science and Engineering. Working in the Banaszak Holl Research Group, his research will be focused on the synthesis and characterization of precisely conjugated dendrimers for application as targeted chemotherapeutic agents.

  Remy Elbez


Chemistry (-present)

Project: 
Advisor: 


About Remy: 

 

Becky Lahti Matz, B.S.

B.S. Chemistry
University of Illinois at Urbana-Champaign

Ph.D. candidate
Department of Chemistry (2007-present)

Project: Establishing if Transfection Requires Degradation of the Nuclear Membrane that Occurs During Mitosis
Advisor: Mark Banaszak Holl, PhD

 

About Becky: Becky graduated with a B.S. in Chemistry from the University of Illinois in 2007 where she did research with Scott Silverman on catalytic DNA. At Michigan, Becky is working towards a Ph.D. in Chemistry. Her research focuses on understanding the mechanisms of non-viral gene delivery. She is also working towards an M.S. in Post-Secondary Science Education under the guidance of Joe Krajcik.

Blake Erickson, B.S.

B.S. Creative studes (Physics) 
University of California, Santa Barbara
B.A. Creative studes (Literature) 
University of California, Santa Barbara

University of Michigan Ph.D. Candidate program in Biophysics
Project:
Functional Imaging and Mechanics of Nanoscale Biological Systems

Advisor:
Mark Banaszak Holl
, PhD

About Blake: Blake graduated from the University of California, Santa Barbara in 2006.  He spent two years in Paul Hansma's lab studying the fracture mechanics of trabecular bone.  At Michigan, he has focused on adapting and applying Atomic Force Microscopy to biological systems.  He is currently looking at the properties of supported lipid bilayers and bone. Outside of the lab, Blake splits his free time ballroom dance and photography.

Recent publications:
Interaction of Poly(amidoamine) Dendrimers with Survanta Lung Surfactant:  The Importance of Lipid Domains B. Erickson, S. DiMaggio, D. G. Mullen, C. V. Kelly, P. R. Leroueil, S. A. Berry, J. R. Baker, Jr., B. G. Orr, M. M. Banaszak Holl, Langmuir 2008 24 11003-11008

(link)

Blake Erickson CV

Rahul Rattan, M.S.

B.E. Biotechnology
Panjab University, India

University of Michigan Ph.D. degree program Biomedical Engineering


Project: 
Advisor: Mark Banaszak Holl
, PhD

About Rahul:  Rahul graduated from Panjab University, India in 2006 with a BE in Biotechnology. He is currently pursuing a PhD in Biomedical Engineering. He is characterizing the impact of dendrimer based drug delivery on mammalian cells specifically the way these interact with cell membranes and enter cells.

Recent Publications:

The Role of Ganglioside GM1 in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers

 

S. Hong, R. Rattan, I. Majoros, D. G. Mullen, J. L. Peters, X. Shi, A. U. Bielinska, L. Blanco, B. G. Orr. J. R. Baker, M. M. Banaszak Holl  Bioconjugate Chemistry  2009,  20,  1503-1513.

L. Devon Triplett
Ph.D. pre-candidate
Applied Physics (2007-present)

Project: Single molecule force microscopy
Advisors: Brad Orr, PhD and Mark Banaszak Holl, PhD

About Devon: Devon received her B.S. in Physics from Virginia Polytechnic Institute and State University in 2007. She is currently pursing her Ph.D. in Applied Physics under the guidanc
e

of Professors Banaszak Holl and Orr. Her research investigates the interaction between folic acid and folate binding protein at the single molecule level using atomic force microscopy.


Recent Publications

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes C. V. Kelly, M. G. Liroff, L. D. Triplett, P. R. Leroueil, D. G. Mullen, J. M. Wallace, S. Meschinchi, J. R. Baker, B. G. Orr, M. M. Banaszak Holl ACS Nano 2009 3, 1886-1896.

Jiumei Chen, M.S.

Ph.D. program in Macromolecular Science and Engineering

B.E., B.A 
Tianjin University
M.S. 
Wayne State University 

About Jiumei: She earned a double major at Tianjin University with a Bachelors of Engineering in Polymer Materials and Engineering and a Bachelors of Arts in English. 

She then earned an MS in Materials Science and Engineering from Wayne State University.  She is now in the Nanobiology certificate program using patch clamp techniques to study the interactions between nanoparticles and biological membranes.  This work will help to provide an understanding of nanoparticle toxicity and the mechanism of DNA transfection.

Awards

October 2006, Materials Incorporated Award in recognition of her academic excellence in the Macromolecular Science and Engineering Center. The award was presented at the banquet of the annual symposium.

2009, the Distinguished Achievement Award from the Macromolecular Science and Engineering Program.

Ajdin Kavara, B.S.

Ph.D. Candidate in Chemistry

B.S. Chemistry, Grand Valley State University, 2004.

About Ajdin: He is from Capljina, Bosnia & Hercegovinia.  He moved to Grand Rapids, Michigan in 1997 and earned his B.S. in chemistry from Grand Valley State University in 2004.  He did his undergraduate research with Prof. Kovacs on heterogeneously catalyzed breakdown of sugars.  His PhD work is focused on CH-

activation chemistry using Sn, applications of the products to cross-coupling chemistry, and novel approaches to natural products, an application within the Nanoscience graduate program.

In 2009, Ajdin received the Peter A. S. Smith fellowship for research in synthetic organic or inorganic chemistry.

Publications

A Stannylene/Aryl Iodide Reagent for Allylic CH-Activation and  Double Bond Addition Chemistry

A. Kavara, K. D. Cousineau, A. D. Rohr, J. W. Kampf, and M. M. Banaszak Holl Organometallics 2008 27 1041-1043

Direct Formation of Propargyl-Tin Compounds via CH-Activation

A. Kavara, J. W. Kampf, M. M. Banaszak Holl Organometallics 2008 27 2896-2897

Tin Mediated CH-Activation and Cross-Coupling in a Single Flask.

J. M. Bartolin, A. Kavara, J. Kampf, M. M. Banaszak Holl. Organometallics 2006, 25, 4738-4740.

Damian Khan, B.S.

University of Michigan PhD program in Applied Physics

Bachelor of Science
Morehouse College

Master of Science
Clark Atlanta University

 

Damian Khan received a B.S. in physics from Morehouse College and an M.S. in physics from Clark Atlanta University. He is currently an applied physics graduate student working with the Orr group and Banaszak Holl groups where he does STM imaging of coated gold surfaces as part of the Nanoscience graduate program.

Publications

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

J. Chen, J. A. Hessler, K. Putchakayala, B. K. Panama, D. P. Khan, S. Hong, D. G. Mullen, S. C. DiMaggio, A. Som, G. N. Tew, A. N. Lopatin, J. R. Baker, M. M. Banaszak Holl, B. G. Orr Journal of Physical Chemistry B 2009, 113, 11179-11185

Nanotexturing Gold Surface with Dendrimers for Selective Cell Adhesion, M.

B. Shenai, D. P. Khan, K. G. Putchakayala, A. K. Patri, A. U. Bielinksa, B. G. Orr, M. M. Banaszak Holl, J. R. Baker. Proc. IEEE EMBC 2003, 1, 1232-1235.

Ming-Hsin Li, M.S.

PhD student, Biomedical Engineering, University of Michigan, 2007- present

BS, Chemical Engineering

Chung Yuan Christian University, 1999

MS, Chemical Engineering

National Taiwan University, 2001

Advisors: James R. Baker, MD and Seok Ki Choi, PhD

About Ming-Hsin:

Project 1: Dendrimer-based multivalent methotrexates as bi-functional therapeutics

Folate binding protein (FBP)-targeted nanodevice has been widely studied to treat site-specifically on tumor cells and tissues for decades, already showing therapeutic efficacy in vitro and in vivo. Based on this rational design, we covalently conjugated methotrexate (MTX), a weakly binding ligand of FBP, onto poly(amidoamine) generation 5 (PAMAM G5) dendrimer to construct a potential targeting polymer therapeutic. To demonstrate binding affinity of the MTX-nanoconjugate to FBP and multivalency-enhanced avidity, a surface plasmon resonance (SPR) biosensor was applied to measure for this system. According to results of SPR, the multivalent MTX-coupled PAMAM dendrimer showed enhanced avidity to immobilized FBP. We also conducted cell based experiments to test the biological activity of this nanodevice. The MTX-presented PAMAM dendrimer was able to cause cytotoxicty in FBP-overexpressed cells.

Project 2: engineering synthetic mimics of DNA-protein recognition systems

Recognition of protein on specific DNA segment initiates subsequent gene expressions and launches diversely enormous biological reactions. This accurate recognition process is believed that a preceding non-specific searching, mainly electrostatic interaction, facilitates the followed specific targeting.  In this study we intend to engineer surface charge on PAMAM dendrimer, to mimic DNA-binding protein and simulate its behavior on DNA segments. By using single molecule detection technique, we are able to visualize the process in real-time.   

Awards and Honors

President's Award, Chung Yuan Christian University (1999)

The 2nd Prize of Poster Context, 39th Annual of Chinese Society of Microbiology (2005)

Study abroad Fellowship, Ministry of Education, Taiwan (2007~2008)

Patent

US Patent: Novel Biological Flocculants and Production Methods (Published Application No. 20040219619651)

Publications  

Ming-Hsin Li, Shang-Ting Tsai, Chung-Hsuan Chen, Chiu Wen Chen, Yuan Tseh Lee, Yi-Sheng Wang, Sensitive Bipolar Ion Detector Based on Sequential Conversion Reactions, Analytical Chemistry 2007, 79, 1277-1282 (cover article)

Posters

Ming-Hsin Li, Seok Ki Choi, Thommey P. Thomas, Alina Kotlyar, Suyang Qin, James R baker, Dendrimer-based multivalent methotrexates as dual acting nanoconjugates in cancer cell targeting, 4th annual NCI alliance for nanotechnology in cancer investigators meeting, Manhattan Beach, CA, Oct 20-22, 2009.

Asish Misra, B.S.

MD/PhD Program, University of Michigan

SB.S. Chemical Engineering, MIT, 2008

SB.S. Electrical Engineering and Computer Science, MIT 2008

Minors in Math, Biomedical Engineering

 

About Asish Misra: During his research rotation in MNIMBS, Asish Misra' reseach was focused on macrophages that have been implicated in many disease processes, from synovial inflammation in rheumatoid arthritis to angiogenesis in tumors. The macrophages in these pathophysiologies often overexpress particular receptors that can be exploited to deliver therapeutics exclusively to these cells. In particular, we are studying the folate receptor and mannose receptors as potential targets.

Publications

C. J. Bettinger, J. P. Bruggeman, A. Misra, J. T. Borenstein, and R. Langer. Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering. Biomaterials, vol. 30, no. 17, pp. 3050-3057, 2009.

C.J. Bettinger, B. Orrick, A. Misra, R. Langer and J.T. Borenstein. Microfabrication of poly(glycerol-sebacate) for contact guidance applications. Biomaterials 27, pp. 2558–2565, 2006.

T. R. F. Fulford-Jones, D. Ruan, W. R. Chan, K. Hartman, A. M. Heafitz, A. C. Misra, T. B. Mloduchowski. The Mars Gravity Biosatellite: Innovations in Murine Motion Analysis and Life Support. Proceedings of the 2005 International Conference on Environmental Systems, July 2005.

 

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