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Bhattacharjee, Somnath, PhD, Research Investigator


9346 MSRB III
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5648
Phone: 734-647-0052

Dr. Bhattacharjee obtained his PhD degree (2008) in Organic Chemistry at Michigan State University in Lansing Michigan. He pursued postdoctoral research work in various areas of chemistry while working with people of diverse research backgrounds. While working in Prof. Merlin Bruening’s laboratory at Michigan State University, Dr. Bhattacharjee developed simple and cost effective methodologies to functionalize membranes with polymer brushes and polyelectrolytes for tag protein purification. He prepared a Pd nanoparticle catalyst that showed much higher reactivity and regioselectivity in the hydrogenation of monosubstituted over multisubstituted double bonds than that of Wilkinson’s catalyst.  Additionally, he developed a methodology to engineer polymer conjugates with protein therapeutics and tested pharmacokinetic properties of the conjugates during his work in Prof. Ashutosh Chilkoti’s laboratory at Duke University. His invention was commercialized.

 Dr. Bhattacharjee joined the Michigan Nanotechnology Institute for Medicine and Biological Sciences in late 2015. His research interests focus on design and synthesis of fine materials for the detection and imaging of cancer cells as well as delivery of small and macromolecules to specific target for the treatment of cancer and cardiovascular diseases.  Dr. Bhattacharjee collaborates with fellow members of MNIMBS.  

Representative Publications:

Otis JB, Zong H, Kotylar A, Yin A, Bhattacharjee S, Wang H, Baker Jr. JR,  Wang SH. Dendrimer Antibody Conjugate to Target and Image HER-2 Overexpressing Cancer CellsOncotarget 2016 Jun 14; 7(24): 36002-36013. PMCID: PMC5094978

Kratz JD, Chaddha, A, Bhattacharjee S, Goonewardena SN. Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications. Cardiovasc Drugs Ther, 2016; 30(1): 33-39. 

Bhattacharjee S, Chilkoti A. Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation. Chembiochem 2015; 16(17): 2451-5 PMCID: PMC4802966.

Liu J, Liu W, Weitzhandler I, Li X,  Wang J, Bhattacharjee S, Chilkoti A. Ring-Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well-Defined Drug-Loaded Nanoparticles. Angew Chem Int Ed Engl 2015; 54(3): 1002-6 PMCID: PMC4293338.

Ma Y,* Dong J,* Bhattacharjee S,* Wijeratne S, Bruening ML, Baker GL. Increased Protein Sorption in Poly(acrylicacid)-Containing Films Through Incorporation of Comb-like Polymers and Film Adsorption at Low pH and High Ionic Strength. Langmuir 2013; 29(9): 2946-54 (*equal contribution) PMCID: PMC3727236. 

Bhattacharjee S, Dong J, Ma Y, Hovde S, Geiger JH, Baker GL, Bruening ML. Formation of High-Capacity Protein-Adsorbing Membranes Through Simple Adsorption of Poly(acrylic acid)-Containing Films at low pH. Langmuir 2012; 28(17): 6885-92  PMCID: PMC3361728.

Anuraj N, Bhattacharjee S, Baker GL, Bruening ML. An All-Aqueous Route to Polymer Brush-Modified Membranes with High Permeabilites and Protein Capture Rates. J Memb Sci 2012; 389: 117-125 PMCID: PMC3265391.

Bhattacharjee S, Bong D. Protein-Polymer Grafts via a Soy Protein Derived Macro-RAFT Chain Transfer Agent. J Polym Environ 2011, 203.


Patents: 

Bruening ML, Baker GL, Bhattacharjee S, Ma Y. Functionalization of a porous membrane with an adsorbed polyacid.  U.S. Pat. Appl. 2013, US 20130244338 A1



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